Ultrafiltration (UF) membrane solutions

Ultrafiltration (UF)

A Polymeric Membrane Solution

Ultrafiltration Overview




Operating Efficiencies

Peace of Mind

What is Ultrafiltration?

In the spectrum of membrane technology, UF has smaller pore sizes than microfiltration MF and uses size exclusion for rejection of particles in the micrometer to nanometer size range.  Examples of solids that will not pass through the membrane into permeate include proteins, fats, bacteria, and suspended solids greater than 0.01-0.1 µ, or with a molecular weight cut-off (“MWCO”) of 1,000 Da (1kDa) to 1,000,000 Da (1,000 kDa).  Other high value materials such as sugars, dissolved salts, and lower molecular weight molecules will pass through into permeate, making this format attractive as a bulk concentration/fractionation step where the enrichment of macromolecules is desired.


While there are many form factors (e.g. tubular, spiral wound, plate and frame) and materials of construction (e.g. polymeric, ceramic) for Ultrafiltration, the most commonly used is polymeric spiral-wound technology.  Solecta is proud to offer polyethersulfone (PES) or polysulfone (PS) polymer spiral-wound membranes in a variety of pore sizes and feed spacers to accommodate the needs of numerous process applications.

Benefits of Ultrafiltration

What are some key benefits of Ultrafiltration?

When properly designed and operated, UF and specifically spiral-wound membranes can offer several benefits over traditional separation process:

  1. Compact footprint
    With advances in element construction and system design, substantial surface area can be designed into a membrane solution vs traditional filtration technologies
  2. Lower energy consumption
    These systems generally consume less energy than other complex separation processes, particularly if they are thermally driven
  3. Minimized waste generation
    With proper operational protocols, including cleaning procedures, UF membranes can generally run with a higher proportion of runtime vs cleaning/downtime
  4. Ease of operation
    UF membrane operations are well understood, and control systems can ensure smooth, safe separation operations
  5. Lower cost of operation
    When considering capital and operating costs, including those mentioned above, UF membranes offer an attractive solution for filtration based on size exclusion of 0.01-0.1 µ or 1-100 kD.
Our Value Proposition In Action:

Continuous Improvement

Results In Nearly 400,000 lbs Additional Product for Sale

The Client has made significant progress in achieving CI goals, realizing more than $395,000  through increased WPC yields and improvements in cheese quality.

Industrial Applications of Ultrafiltration

UF is used broadly across process industries, most namely dairy, food ingredients, biotechnology/life sciences, beverages, and automotive manufacturing operations.  Some of the key applications across these industries include the following:


  • WPC and WPI production (protein fractionation/concentration)
  • Milk production (protein fractionation/concentration)

Food Ingredients

  • Sugar/sweetener processing (dextrose clarification prior to refining)
  • Gelatin processing (protein concentration)
  • Edible oils (phosphatide removal, degumming)
  • Other fermentation processes (clarification)

fermented food ingredients

Life Science

  • Cell mass removal (downstream processing of bulk fermentation)

wine ultrafiltration


  • Beer, wine, and juice production (color removal and clarification)

rinse bath


  • Paint recovery (clarification)

reverse osmosis


  • Oil-water separation (for water/waste treatment and/or recovery of oils)

FAQs on Ultrafiltration

The typical Ultrafiltration separation process is based on a sieving mechanism, with pores sizes between 0.01 and 0.1 μm, or 1-100 kD.

As fluids pass through, usually in a cross-flow configuration with low transmembrane pressures (TMPs) of 50-120 psi or 3.5-8 bar, the membranes retain those particles in a process stream called retentate. The fluid that passes through the membrane is referred to as permeate.

As the membranes separate solids, particles can agglomerate at the membrane surface, causing what is referred to as fouling.  This phenomenon can slow down the flow rate and/or increase pressure across the membrane, if the process is not optimized.  Maintaining proper operational best practices, such as backwashing in some membrane formats and/or cleaning procedures in others, can prevent fouling.  Automation can also help detect this by monitoring flow and/or pressure drop across the membrane.

Ultrafiltration systems are very robust and typically require little routine maintenance.  When they do, it is recommended that qualified technicians work on these systems to maintain optimal performance.  Some of the typical maintenance tasks around Ultrafiltration system maintenance include:

  • Pre-treatment system – some membrane systems might include a pre-treatment step, such as cartridge filters or MF membranes. These will need to be exchanged periodically to maintain Ultrafiltration system performance.
  • Gauges and other instrumentation – as these systems typically include both manual and automated instrumentation, it is important to check and ensure these are operating correctly. In the case of automation, it is important to calibrate these instruments per the manufacturers’ recommended protocol.
  • Valves, solenoids, and other wear parts – it is not uncommon for valves to become stuck and/or freeze, particularly if they are not exercised during normal operations. It is important to turn valves off and on periodically, as well as check to ensure solenoids are operating correctly, to maintain system reliability.
  • Element replacement – when a membrane has gone past its useful life, it will need to be replaced. Loss of performance will typically manifest itself in reduced rejection or clarification results and/or through changes in flow rate.  Ensure that technicians are qualified to replace elements, so they don’t damage elements upon installation, and also ensure proper seals to prevent system leakage.

Otherwise, Ultrafiltration systems will typically have an on-going cleaning protocol, which maintains the health and reliability of the membrane system.  These cleaning chemicals will ensure proper flow and rejection, as well as prevent unwanted microbiological contamination – ensuring optimal performance and sanitary conditions.

Ultrafiltration concentrates particles that are greater than 0.01 µ or 1kD.  These particles include a number of materials, including, but not limited to:

  • Virus
  • Bacteria
  • Algae
  • Fungi
  • Yeast cells
  • Microorganisms
  • Fats
  • Proteins

Ultrafiltration membranes can be constructed of either ceramic or polymeric materials.  In the case of polymeric Ultrafiltration membranes, the specific polymers are typically offer polyethersulfone (PES) or polysulfone (PS).

Form factors for Ultrafiltration include tubular (shell and tube design), plate and frame (membrane flat sheet sandwiched in between support plates), hollow fiber (comparable to a straw), and spiral-wound (alternating layers of flat sheet, feed spacer, and permeate carrier).

The most common Ultrafiltration membranes are polymeric, spiral-wound configurations.

Feed – The process stream that enters the membrane for clarification and/or fractionation

Flux – The rate of extraction of permeate, which is typically measured in LMH (liters per square meter of membrane surface per hour – l/m2/h) or GFD (gallons per square foot of membrane surface per day – gal/ft2/day)

Fouling – The deposition of solids on the surface of a membrane

Permeate – The liquid stream that passes through the membrane (aka filtrate)

Retentate –The liquid stream that is rejected by the membrane (aka concentrate)

Concentration Factor – The ratio of initial feed volume to retentate or concentrate, which is an indication of target volume reduction achieved by membrane filtration

Diafiltration – The use of water (or another solvent) with the intent to increase the passage of soluble materials into the permeate (such as lactose or minerals) and increase the purity of components in the concentrate, such as protein

More Polymeric Membrane Solutions

Nanofiltration (NF)

Learn More

Reverse Osmosis (RO)

Learn More

Microfiltration (MF)

Learn More

Ready To Optimize Your Membrane Processes?

Let’s Chat